Elevated serum retinol-binding protein 4 concentrations are associated with chronic kidney disease but not with the higher carotid intima-media thickness in type 2 diabetic subjects

Chih-Hsun Chu; Hing-Chung Lam; Jenn-Kuen Lee; Chih-Chen Lu; Chun-Chin Sun; Hsin-Ju Cheng; Mei-Chun Wang; Ming-Ju Chuang

doi:10.1507/endocrj.EJ11-0028

ORIGINALS

Elevated serum retinol-binding protein 4 concentrations are associated with chronic kidney disease but not with the higher carotid intima-media thickness in type 2 diabetic subjects

Chih-Hsun Chu, Hing-Chung Lam, Jenn-Kuen Lee, Chih-Chen Lu, Chun-Chin Sun, Hsin-Ju Cheng, Mei-Chun Wang, Ming-Ju Chuang

Author information

Chih-Hsun Chu
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Department of Rehabilitation Technology, TzuHui Institute of Technology, Pingtung, Taiwan
Hing-Chung Lam
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Faculty of Nursing, Yuh-Ing Junior College of Health Care and Management, Kaohsiung, Taiwan
Jenn-Kuen Lee
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Chih-Chen Lu
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Chun-Chin Sun
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Hsin-Ju Cheng
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Mei-Chun Wang
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Ming-Ju Chuang
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Keywords: Retinol-binding protein 4, Carotid intima-media thickness, Estimated glomerular filtration rate, Microalbuminuria

JOURNAL FREE ACCESS

2011 Volume 58 Issue 10 Pages 841-847

DOI https://doi.org/10.1507/endocrj.EJ11-0028

View "Advance Publication" version (August 4, 2011).

Details

Abstract

To examine the association of serum retinol-binding protein 4 (RBP4) concentrations with carotid intima-media thickness (CIMT) in type 2 diabetic subjects with chronic kidney disease (CKD). A total of 239 type 2 diabetic patients (64 ± 13 years, 154 males) were divided into two groups: one with CKD, defined as estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73m² (n = 86), and one without (n = 153). We recorded clinical and biochemical data as well as CIMT. The patients with CKD were older, had had diabetes mellitus longer, and had higher incidence of hypertension, dyslipidemia and microalbuminuria than those without. They also had higher serum concentrations of RBP4 (44.8 ± 6.4 vs 39.5 ± 4.9 μg/mL, p < 0.001), higher mean CIMT (0.75 ± 0.16 vs 0.69 ± 0.14 mm, p = 0.0070), and higher incidence of carotid plaques (27.9 vs 11.8 %, p = 0.002). The RBP4 were negatively correlated with eGFR (r = -0.514, p < 0.001). However, the RBP4 were not correlated with mean CIMT (r = 0.065, p = 0.318). Moreover, when dividing the patients into two groups by the mean CIMT, those with mean CIMT above 0.71 mm did not have different RBP4 concentrations compared with those below (41.5 ± 5.7 vs 41.3 ± 6.3 μg/mL, p = 0.856). In conclusion, we observed an elevation of serum RBP4 concentrations and CIMT levels in type 2 diabetic subjects with CKD. However, the elevated RBP4 were not associated with the higher CIMT among these patients.

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