Prognosis of Patients with Papillary Carcinoma Showing Anaplastic Transformation in Regional Lymph Nodes that Were Curatively Resected

Yasuhiro ITO; Takuya HIGASHIYAMA; Mitsuyoshi HIROKAWA; Mitsuhiro FUKUSHIMA; Hiroyuki INOUE; Tomonori YABUTA; Chisato TOMODA; Takashi URUNO; Minoru KIHARA; Yuuki TAKAMURA; Akihiro MIYA; Kaoru KOBAYASHI; Fumio MATSUZUKA; Akira MIYAUCHI

doi:10.1507/endocrj.K08E-148

ORIGINALS

Prognosis of Patients with Papillary Carcinoma Showing Anaplastic Transformation in Regional Lymph Nodes that Were Curatively Resected

Yasuhiro ITO, Takuya HIGASHIYAMA, Mitsuyoshi HIROKAWA, Mitsuhiro FUKUSHIMA, Hiroyuki INOUE, Tomonori YABUTA, Chisato TOMODA, Takashi URUNO, Minoru KIHARA, Yuuki TAKAMURA, Akihiro MIYA, Kaoru KOBAYASHI, Fumio MATSUZUKA, Akira MIYAUCHI

Author information

Yasuhiro ITO
Department of Surgery, Kuma Hospital
Takuya HIGASHIYAMA
Department of Surgery, Kuma Hospital
Mitsuyoshi HIROKAWA
Department of Pathology, Kuma Hospital
Mitsuhiro FUKUSHIMA
Department of Surgery, Kuma Hospital
Hiroyuki INOUE
Department of Surgery, Kuma Hospital
Tomonori YABUTA
Department of Surgery, Kuma Hospital
Chisato TOMODA
Department of Surgery, Kuma Hospital
Takashi URUNO
Department of Surgery, Kuma Hospital
Minoru KIHARA
Department of Surgery, Kuma Hospital
Yuuki TAKAMURA
Department of Surgery, Kuma Hospital
Akihiro MIYA
Department of Surgery, Kuma Hospital
Kaoru KOBAYASHI
Department of Surgery, Kuma Hospital
Fumio MATSUZUKA
Department of Surgery, Kuma Hospital
Akira MIYAUCHI
Department of Surgery, Kuma Hospital

Keywords: Anaplastic carcinoma, Thyroid, Lymph node metastasis

JOURNAL FREE ACCESS

2008 Volume 55 Issue 6 Pages 985-989

DOI https://doi.org/10.1507/endocrj.K08E-148

View "Advance Publication" version (July 9, 2008).

Details

Abstract

Anaplastic carcinoma arises from differentiated carcinoma and generally shows a dire prognosis. Anaplastic transformation may occur not only in primary tumors but also in metastatic lymph nodes. We encountered 5 cases of papillary carcinoma showing anaplastic transformation in lymph nodes that were curatively resected. Patient ages ranged from 67 to 85 years. Two of these patients showed anaplastic transformation at the initial surgery and the remaining 3 showed anaplastic transformation after repeated recurrence to the lymph nodes. After resection of anaplastic lesions of the nodes, 2 patients underwent radiation therapy, whereas the remaining 3 did not receive any adjuvant therapy. One patient died of rapid growth of lung metastasis 5 months after the resection. One patient died of carcinoma 63 months after surgery. Two patients have survived to date, 6 and 85 months after resection, respectively. The remaining one patient died of heart failure 11 months after surgery. It is therefore suggested that long-term survival can be expected for patients with differentiated carcinoma showing anaplastic transformation in the lymph node if the lesions can be curatively resected.

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