Inhibitory Effect of Apple Pectin and Culture Condensate of Bifidobacterium longum on Colorectal Tumors Induced by 1,2-Dimethylhydrazine in Transgenic Mice Harboring Human Prototype c-Ha-ras Genes

Kazuko OHNO; Seiko NARUSHIMA; Satomi TAKEUCHI; Kikuji ITOH; Tomotari MITSUOKA; Hiroyuki NAKAYAMA; Toshio ITOH; Kyoji HIOKI; Tatsuji NOMURA

doi:10.1538/expanim.49.305

Note

Inhibitory Effect of Apple Pectin and Culture Condensate of Bifidobacterium longum on Colorectal Tumors Induced by 1,2-Dimethylhydrazine in Transgenic Mice Harboring Human Prototype c-Ha-ras Genes

Kazuko OHNO, Seiko NARUSHIMA, Satomi TAKEUCHI, Kikuji ITOH, Tomotari MITSUOKA, Hiroyuki NAKAYAMA, Toshio ITOH, Kyoji HIOKI, Tatsuji NOMURA

Author information

Kazuko OHNO
Laboratory of Veterinary Public Health, Graduate School of Agriculture and Life Science, The University of Tokyo
Seiko NARUSHIMA
Laboratory of Veterinary Public Health, Graduate School of Agriculture and Life Science, The University of Tokyo
Satomi TAKEUCHI
Laboratory of Veterinary Public Health, Graduate School of Agriculture and Life Science, The University of Tokyo
Kikuji ITOH
Laboratory of Veterinary Public Health, Graduate School of Agriculture and Life Science, The University of Tokyo
Tomotari MITSUOKA
Laboratory of Veterinary Public Health, Graduate School of Agriculture and Life Science, The University of Tokyo
Hiroyuki NAKAYAMA
Laboratory of Veterinary Pathology, Graduate School of Agriculture and Life Science, The University of Tokyo
Toshio ITOH
Central Institute for Experimental Animals
Kyoji HIOKI
Central Institute for Experimental Animals
Tatsuji NOMURA
Central Institute for Experimental Animals

Keywords: c-Ha-ras gene, colorectal tumor, transgenic mice

JOURNAL FREE ACCESS

2000 Volume 49 Issue 4 Pages 305-307

DOI https://doi.org/10.1538/expanim.49.305

Details

Abstract

The number and tumor score of colorectal tumors induced by 1,2-dymethylhydrazine in transgenic (Tg) mice carrying human c-Ha-ras genes were significantly reduced by ingestion of apple pectin (AP) or a culture condensate of Bifidobacterium longum (MB) when compared with a control diet. There was no statistical difference in the incidence of colorectal tumors in Tg mice between the AP or MB diet and the control diet. This study demonstrated that Tg mice are a useful tool for screening inhibition of colorectal tumors by functional foods.

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