Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Circling Mouse, a Spontaneous Mutant in the Inner Ear
Jeong Woong LEEZae Young RYOOEun Ju LEESung Hwa HONGWon Ho CHUNGHoon Taek LEEKil Saeng CHUNGTae Yoon KIMYang Seok OHJun Gyo SUH
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JOURNAL FREE ACCESS

2002 Volume 51 Issue 2 Pages 167-171

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Abstract

A spontaneous mutant was established in the ICR mouse strain. The affected mice became hyperactive at about 7 days of age, and then showed circling behavior. The body weight decreased significantly 2 weeks after birth, and developmental defects were revealed in the middle ear, cochlea, cochlear nerve, and semicircular canal areas. The mutation was inherited by an autosomal single recessive gene and is referred to as cir.

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© 2002 Japanese Association for Laboratory Animal Science
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