Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
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Evaluation of Blood Pressure in Spontaneously Diabetic Torii-Leprfa Rats
Yukihito ISHIIMimi MAKIHiromi YAMAMOTOTomohiko SASASEMakoto KAKUTANITakeshi OHTA
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JOURNAL FREE ACCESS

2010 Volume 59 Issue 4 Pages 525-529

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Abstract

The Spontaneously Diabetic Torii-Leprfa (SDT-fa/fa) rat, a new model of obese type 2 diabetes, shows obesity, hyperglycemia, and hyperlipidemia from 6 weeks of age. Diabetic complications such as nephropathy and cataract are observed with aging; however, blood pressure change with age has not previously been examined. In this study, blood pressure was periodically measured and the change was investigated. Blood pressure in male SDT-fa/fa rats was elevated at 8, 16, and 24 weeks of age, whereas the heart rate was not changed. In addition to hyperglycemia, hyperlipidemia, and proteinuria, hyperleptinemia and increased urine angiotensinogen were observed in SDT-fa/fa rats. Blood pressure and heart rate in the male original SDT (SDT-+/+) rat did not significantly change. In conclusion, the SDT-fa/fa rat is a promising model, showing significant hypertension with diabetes mellitus.

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© 2010 Japanese Association for Laboratory Animal Science
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