Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Review Series: Frontiers of Model Animals for Human Diseases
Advantages of a Mouse Model for Human Hearing Impairment
Yoshiaki KikkawaYuta SekiKazuhiro OkumuraYasuhiro OhshibaYuki MiyasakaSari SuzukiMao OzakiKunie MatsuokaYoshihiro NoguchiHiromichi Yonekawa
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JOURNAL FREE ACCESS

2012 Volume 61 Issue 2 Pages 85-98

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Abstract

Hearing is a major factor in human quality of life. Mouse models are important tools for discovering the genes that are responsible for genetic hearing loss, and these models often allow the processes that regulate the onset of deafness in humans to be analyzed. Thus far, in the study of hearing and deafness, at least 400 mutants with hearing impairments have been identified in laboratory mouse populations. Analysis of through a combination of genetic, morphological, and physiological studies is revealing valuable insights into the ontogenesis, morphogenesis, and function of the mammalian ear. This review discusses the advantages of the mouse models of human hearing impairment and highlights the identification of the molecules required for stereocilia development in the inner ear hair cells by analysis of various mouse mutants.

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© 2012 Japanese Association for Laboratory Animal Science
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