Anti-tumor effects of prostaglandin D2 and its metabolites, 15-deoxy-Δ12, 14-PGJ2, by peroxisome proliferator-activated receptor (PPAR) γ-dependent and -independent pathways.

Masaki Nakamura; Shohei Yamaguchi; Katsuaki Motoyoshi; Miku Negishi; Tatsuo Saito-Taki; Kazumasa Matsumoto; Izumi Hayashi; Masataka Majima; Hidero Kitasato

doi:10.2492/inflammregen.31.189

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Anti-tumor effects of prostaglandin D₂ and its metabolites, 15-deoxy-Δ^{12, 14}-PGJ₂, by peroxisome proliferator-activated receptor (PPAR) γ-dependent and -independent pathways.

Masaki Nakamura, Shohei Yamaguchi, Katsuaki Motoyoshi, Miku Negishi, Tatsuo Saito-Taki, Kazumasa Matsumoto, Izumi Hayashi, Masataka Majima, Hidero Kitasato

Author information

Masaki Nakamura
Department of Environmental Microbiology, Kitasato University Graduate School of Medical Sciences
Shohei Yamaguchi
Department of Microbiology, Kitasato University School of Allied Health Sciences
Katsuaki Motoyoshi
Department of Microbiology, Kitasato University School of Allied Health Sciences
Miku Negishi
Department of Microbiology, Kitasato University School of Allied Health Sciences
Tatsuo Saito-Taki
Department of Environmental Microbiology, Kitasato University Graduate School of Medical Sciences
Department of Microbiology, Kitasato University School of Allied Health Sciences
Kazumasa Matsumoto
Department of Urology, Kitasato University School of Medicine
Izumi Hayashi
Department of Pathophysiology, Nihon Pharmaceutical University
Masataka Majima
Department of Pharmacology, Kitasato University School of Medicine
Hidero Kitasato
Department of Environmental Microbiology, Kitasato University Graduate School of Medical Sciences
Department of Microbiology, Kitasato University School of Allied Health Sciences

Keywords: 15d-PGJ₂, anti-tumor effect, cell therapy

JOURNAL FREE ACCESS

2011 Volume 31 Issue 2 Pages 189-195

DOI https://doi.org/10.2492/inflammregen.31.189

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Abstract

Hematopoietic prostaglandin (PG) D synthase (H-PGDS) is known as key enzyme in the production of PGD₂ and its J series metabolite, 15-deoxy-Δ^{12, 14}-PGJ₂ (15d-PGJ₂), is thought to play an important role for anti-inflammatory effects. Anti-tumor effects of 15d-PGJ₂ has been shown to be involved in both peroxisome proliferator-activated receptor (PPAR) γ independent and dependent pathways. The independent pathway includes the repression of the telomerase reverse transcriptase (TERT) and cyclooxygenase (COX)-2 via the down-regulation of NFκB. The dependent pathway included repression of the vascular endothelial growth factor (VEGF) receptors and COX-2 with down-regulation of NFκB, followed by the activation of PPAR γ. In this review, we focused on the role of 15d-PGJ₂ in anti-tumor effects including our evaluation in mouse bladder carcinoma model.

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