Glucocorticoid Therapy Ameliorated Hypoglycemia in Insulin-like Growth Factor-II-producing Solitary Fibrous Tumor

Kiminori Tsuro; Hideyuki Kojima; Shingo Okamoto; Hitoshi Yoshiji; Masao Fujimoto; Masahito Uemura; Masahide Yoshikawa; Takashi Nakamura; Saihou Kou; Yoshiyuki Nakajima; Hiroshi Fukui

doi:10.2169/internalmedicine.45.1611

CASE REPORTS

Glucocorticoid Therapy Ameliorated Hypoglycemia in Insulin-like Growth Factor-II-producing Solitary Fibrous Tumor

Kiminori Tsuro, Hideyuki Kojima, Shingo Okamoto, Hitoshi Yoshiji, Masao Fujimoto, Masahito Uemura, Masahide Yoshikawa, Takashi Nakamura, Saihou Kou, Yoshiyuki Nakajima, Hiroshi Fukui

Author information

Kiminori Tsuro
Third Department of Internal Medicine, Nara Medical University
Hideyuki Kojima
Third Department of Internal Medicine, Nara Medical University
Shingo Okamoto
Third Department of Internal Medicine, Nara Medical University
Hitoshi Yoshiji
Third Department of Internal Medicine, Nara Medical University
Masao Fujimoto
Third Department of Internal Medicine, Nara Medical University
Masahito Uemura
Third Department of Internal Medicine, Nara Medical University
Masahide Yoshikawa
Department of Parasitology, Nara Medical University
Takashi Nakamura
First Department of Surgery, Nara Medical University
Saihou Kou
First Department of Surgery, Nara Medical University
Yoshiyuki Nakajima
First Department of Surgery, Nara Medical University
Hiroshi Fukui
Third Department of Internal Medicine, Nara Medical University

Keywords: insulin-like growth factor-II, glucocorticoid therapy, non-islet cell tumor hypoglycemia (NICTH), solitary fibrous tumor, metastatic liver tumor

JOURNAL OPEN ACCESS

2006 Volume 45 Issue 8 Pages 525-529

DOI https://doi.org/10.2169/internalmedicine.45.1611

Details

Abstract

A 54-year-old man with a past history of multi-operation for solitary fibrous tumor was hospitalized for hypoglycemia. Computed tomography demonstrated multiple tumors in the liver but not in the pancreas. His serum insulin-like growth factor (IGF)-II level was normal, but immunoblot analysis and immunohistochemistry revealed a high molecular weight form of IGF-II in the serum and tumor. Surgical resection was impossible, because of tumor dissemination. Hypoglycemia was repeated despite infusion of glucose and glucagon. Glucocorticoid dramatically and continuously abolished hypoglycemia. In cases of inoperable IGF-II-producing tumor, glucocorticoid therapy may be promising for hypoglycemia.

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