Remission of IgA Nephropathy after Allogeneic Peripheral Blood Stem Cell Transplantation Followed by Immunosuppression for Acute Lymphocytic Leukemia

Yasunori Iwata; Takashi Wada; Akio Uchiyama; Atsuo Miwa; Izaya Nakaya; Tadashi Tohyama; Yuhji Yamada; Toshiro Kurokawa; Takashi Yoshida; Satoshi Ohta; Hitoshi Yokoyama; Hiroyuki Iida

doi:10.2169/internalmedicine.45.1837

CASE REPORTS

Remission of IgA Nephropathy after Allogeneic Peripheral Blood Stem Cell Transplantation Followed by Immunosuppression for Acute Lymphocytic Leukemia

Yasunori Iwata, Takashi Wada, Akio Uchiyama, Atsuo Miwa, Izaya Nakaya, Tadashi Tohyama, Yuhji Yamada, Toshiro Kurokawa, Takashi Yoshida, Satoshi Ohta, Hitoshi Yokoyama, Hiroyuki Iida

Author information

Yasunori Iwata
Department of Internal Medicine, Toyama Prefectural Central Hospital
Takashi Wada
Disease Control and Homeostasis, Kanazawa University Graduate School of Medicine
Akio Uchiyama
Department of Pathology, Toyama Prefectural Central Hospital
Atsuo Miwa
Department of Pathology, Toyama Prefectural Central Hospital
Izaya Nakaya
Department of Internal Medicine, Toyama Prefectural Central Hospital
Tadashi Tohyama
Department of Internal Medicine, Toyama Prefectural Central Hospital
Yuhji Yamada
Department of Internal Medicine, Toyama Prefectural Central Hospital
Toshiro Kurokawa
Department of Internal Medicine, Toyama Prefectural Central Hospital
Takashi Yoshida
Department of Internal Medicine, Toyama Prefectural Central Hospital
Satoshi Ohta
Department of Internal Medicine, Toyama City Hospital
Hitoshi Yokoyama
Department of Nephrology, Kanazawa Medical University
Hiroyuki Iida
Department of Internal Medicine, Toyama Prefectural Central Hospital

Keywords: IgA nephropathy, PBSCT, ALL

JOURNAL OPEN ACCESS

2006 Volume 45 Issue 22 Pages 1291-1295

DOI https://doi.org/10.2169/internalmedicine.45.1837

Details

Abstract

We report a case with immunoglobulin A (IgA) nephropathy, showing IgA deposition which disappeared after peripheral blood stem cell transplantation (PBSCT) for acute lymphocytic leukemia (ALL).
In 1996, a 28-year-old man was diagnosed with IgA nephropathy by renal biopsy. Steroid therapy improved proteinuria from 3 g/day to 1 g/day. In 2003, he received PBSCT following the initial therapy for ALL. After complete remission, urinary protein and hematuria remained at between (-) and (±). In 2004, the second renal biopsy specimen revealed no deposit of IgA or C3. These findings suggested that immune reconstruction with PBSCT following immunosuppression therapy was of benefit to IgA nephropathy.

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