An 85-year-old Case with Hashimoto's Encephalopathy, Showing Spontaneous Complete Remission

Nagaaki Katoh; Takuhiro Yoshida; Yasuhiro Shimojima; Takahisa Gono; Masayuki Matsuda; Makoto Yoneda; Shu-ichi Ikeda

doi:10.2169/internalmedicine.46.0266

CASE REPORTS

An 85-year-old Case with Hashimoto's Encephalopathy, Showing Spontaneous Complete Remission

Nagaaki Katoh, Takuhiro Yoshida, Yasuhiro Shimojima, Takahisa Gono, Masayuki Matsuda, Makoto Yoneda, Shu-ichi Ikeda

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Keywords: Hashimoto's encephalopathy, anti-thyroglobulin antibody, anti-α-enolase antibody, thyroid disease, spontaneous remission

JOURNAL OPEN ACCESS

2007 Volume 46 Issue 18 Pages 1613-1616

DOI https://doi.org/10.2169/internalmedicine.46.0266

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Abstract

We report an 85-year-old man with Hashimoto's encephalopathy (HE) who showed spontaneous complete remission. The autoantibody against the amino (NH₂) terminal region of α-enolase was positive in our patient. Neuropsychological manifestations, such as personality change and progressive cognitive impairment, gradually improved over approximately 6 weeks after onset of disease without corticosteroid treatment in parallel with a decrease in the anti-thyroglobulin antibody in the cerebrospinal fluid. HE should be considered as a possible diagnosis even in elderly patients with neuropsychiatric symptoms, particularly when a previous history of thyroid disease is present.

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