Early Stage of Colonic Adenocarcinoma Associated with Traditional Serrated Adenoma

Hiromitsu Kanzaki; Shoji Hirasaki; Seiyuu Suzuki; Minoru Matsubara; Kohei Fujita; Norio Koide

doi:10.2169/internalmedicine.46.0388

CASE REPORTS

Early Stage of Colonic Adenocarcinoma Associated with Traditional Serrated Adenoma

Hiromitsu Kanzaki, Shoji Hirasaki, Seiyuu Suzuki, Minoru Matsubara, Kohei Fujita, Norio Koide

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Keywords: serrated adenoma-carcinoma sequence, serrated pathway, colonoscopy, sigmoid colon cancer, laparoscopy-assisted sigmoidectomy

JOURNAL OPEN ACCESS

2007 Volume 46 Issue 23 Pages 1911-1914

DOI https://doi.org/10.2169/internalmedicine.46.0388

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Abstract

We describe a 68-year-old woman diagnosed as having a colonic adenocarcinoma associated with traditional serrated adenoma (SA) with submucosal invasion of the sigmoid colon. Colonoscopy revealed a 0-IIa+IIc colon cancer with a SA component, about 12 mm in diameter, in the sigmoid colon. She underwent laparoscopy-assisted resection of the sigmoid colon. In the resected specimen, colon cancer with mucin pools was adjacent to the SA. Cases of colonic adenocarcinoma associated with traditional SA with submucosal invasion are relatively rare. This case suggests that SA may play a role in the development of colorectal cancer.

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