Early Ultrasonographic Diagnosis and Clinical Follow-up of Hepatic Veno-Occlusive Disease after Allogeneic Bone Marrow Transplantation in a Patient with Acute Lymphoblastic Leukemia

Yosuke Matsumoto; Shigeo Horiike; Junichi Sakagami; Yoshiko Fujimoto; Kyoko Taniguchi; Daisuke Shimizu; Kazuho Shimura; Hitoji Uchiyama; Junya Kuroda; Kenichi Nomura; Chihiro Shimazaki; Masafumi Taniwaki

doi:10.2169/internalmedicine.48.1404

CASE REPORTS

Early Ultrasonographic Diagnosis and Clinical Follow-up of Hepatic Veno-Occlusive Disease after Allogeneic Bone Marrow Transplantation in a Patient with Acute Lymphoblastic Leukemia

Yosuke Matsumoto, Shigeo Horiike, Junichi Sakagami, Yoshiko Fujimoto, Kyoko Taniguchi, Daisuke Shimizu, Kazuho Shimura, Hitoji Uchiyama, Junya Kuroda, Kenichi Nomura, Chihiro Shimazaki, Masafumi Taniwaki

Author information

Yosuke Matsumoto
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Shigeo Horiike
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Junichi Sakagami
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Yoshiko Fujimoto
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Kyoko Taniguchi
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Daisuke Shimizu
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Kazuho Shimura
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Hitoji Uchiyama
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Junya Kuroda
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Kenichi Nomura
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Chihiro Shimazaki
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Masafumi Taniwaki
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science

Keywords: ultrasonography, veno-occlusive disease, portal venous flow, bone marrow transplantation

JOURNAL OPEN ACCESS

2009 Volume 48 Issue 10 Pages 831-835

DOI https://doi.org/10.2169/internalmedicine.48.1404

Details

Abstract

Hepatic veno-occlusive disease (VOD) is a typical complication occurring soon after allogeneic hematopoietic stem cell transplantation (HST), characterized by jaundice, painful liver enlargement, and weight gain due to fluid retention. The study reported here concerns a patient with VOD after allogeneic HST. Hemodynamic evaluation using ultrasonography revealed reversed portal venous flow before elevation of serum bilirubin, in addition to gallbladder wall thickening, ascites, and hepatomegaly. Quantitative evaluation using abdominal ultrasonography showed improvement in the reversed portal venous flow before the peaking of the serum bilirubin level and coagulopathy. This analysis was useful for both early diagnosis and clinical follow-up of VOD.

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