Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Glucagonoma Diagnosed by Arterial Stimulation and Venous Sampling (ASVS)
Yukiyoshi Okauchi, Takao Nammo, Hiromi Iwahashi, Takashi Kizu, Isao Hayashi, Kohei Okita, Kazuya Yamagata, Sae Uno, Fumie Katsube, Munehide Matsuhisa, Ken Kato, Katsuyuki Aozasa, Tonsok Kim, Keigo Osuga, Shoji Nakamori, Yasuhiro Tamaki, Tohru Funahashi, Jun-ichiro Miyagawa, Iichiro Shimomura
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Keywords: multiple endocrine neoplasia type 1, arterial stimulation and venous sampling, glucagonoma
JOURNAL OPEN ACCESS

2009 Volume 48 Issue 12 Pages 1025-1030

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Abstract

To identify the location of pancreatic endocrine tumors, arterial stimulation and venous sampling (ASVS) is known to be useful for insulinoma and gastrinoma, but its usefulness for glucagonoma has not been verified to date. Here we report a case of glucagonoma that was diagnosed by ASVS with calcium loading, in which an approximately 6-fold increase of glucagon was observed in the splenic artery territory. MEN1 gene analysis verified the presence of a mutation and the glucagonoma was confirmed after operation. In conclusion, ASVS could be useful for the diagnosis of glucagonoma.

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© 2009 by The Japanese Society of Internal Medicine
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