Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Acute Kidney Injury Caused by Zonisamide-Induced Hypersensitivity Syndrome
Yoshiro FujitaMidori HasegawaKuihiro NabeshimaMakoto TomitaKazutaka MurakamiShigeru NakaiTakashi YamakitaKayoko Matsunaga
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JOURNAL OPEN ACCESS

2010 Volume 49 Issue 5 Pages 409-413

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Abstract

Drug rash with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a severe adverse drug reaction affecting multiple organs caused by drug treatment. The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer. Hypersensitivity to zonisamide was confirmed by the skin patch test. Based on these findings, the patient was diagnosed with DRESS/DIHS caused by zonisamide. This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.

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© 2010 by The Japanese Society of Internal Medicine
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