Successful Allogeneic Bone Marrow Transplantation for Diamond-Blackfan Anemia Complicated by Severe Cardiac Dysfunction due to Transfusion-Induced Hemochromatosis

Sumie Tabata; Minako Mori; Yuya Nagai; Hisako Hashimoto; Hiroshi Arima; Seiji Nagano; Yoko Takiuchi; Daichi Inoue; Takaharu Kimura; Sonoko Shimoji; Soshi Yanagita; Kiminari Ito; Akiko Matsushita; Kenichi Nagai; Takayuki Takahashi

doi:10.2169/internalmedicine.49.2991

CASE REPORTS

Successful Allogeneic Bone Marrow Transplantation for Diamond-Blackfan Anemia Complicated by Severe Cardiac Dysfunction due to Transfusion-Induced Hemochromatosis

Sumie Tabata, Minako Mori, Yuya Nagai, Hisako Hashimoto, Hiroshi Arima, Seiji Nagano, Yoko Takiuchi, Daichi Inoue, Takaharu Kimura, Sonoko Shimoji, Soshi Yanagita, Kiminari Ito, Akiko Matsushita, Kenichi Nagai, Takayuki Takahashi

Author information

Sumie Tabata
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
Minako Mori
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
Yuya Nagai
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
Hisako Hashimoto
Department of Hematology, Institute of Biomedical Research and Innovation
Hiroshi Arima
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
Seiji Nagano
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
Yoko Takiuchi
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
Daichi Inoue
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
Takaharu Kimura
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
Sonoko Shimoji
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
Soshi Yanagita
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
Kiminari Ito
Department of Hematology, Institute of Biomedical Research and Innovation
Akiko Matsushita
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
Kenichi Nagai
Department of Hematology, Institute of Biomedical Research and Innovation
Takayuki Takahashi
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital

Keywords: allogeneic bone marrow transplantation, diamond-blackfan anemia, cardiac dysfunction, hemochromatosis

JOURNAL OPEN ACCESS

2010 Volume 49 Issue 5 Pages 453-456

DOI https://doi.org/10.2169/internalmedicine.49.2991

Details

Abstract

A 21-year-old man who was diagnosed with Diamond-Blackfan anemia at 2 years of age came to our hospital with the hope of undergoing bone marrow transplantation (BMT). He had been red cell transfusion-dependent for about 8 years; at presentation he had transfusion-induced hemochromatosis, a subsequent low left ventricular ejection fraction (LVEF) of 43%, and diabetes mellitus requiring insulin therapy. He received unrelated BMT with reduced intensity conditioning and sufficient GVHD prophylaxis. Regardless of the cardiac dysfunction, he had an uneventful course during pre- and post-grafting periods, and is currently doing well with an improved LVEF (55%), although he is still insulin dependent.

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