Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Successful Allogeneic Hematopoietic Stem Cell Transplantation for Aggressive NK Cell Leukemia
Satoshi IchikawaNoriko FukuharaJoji YamamotoMakiko SuzukiShinji NakajimaYoko OkitsuKatsura KohataYasushi OnishiKenichi IshizawaJunichi KameokaHideo Harigae
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JOURNAL OPEN ACCESS

2010 Volume 49 Issue 17 Pages 1907-1910

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Abstract

Aggressive natural killer cell leukemia (ANKL) is a highly aggressive lymphoproliferative disease. An appropriate therapeutic strategy for ANKL remains to be established, but a few case reports have suggested that allogeneic hematopoietic stem cell transplantation (allo-HCT) can be curative. Here, we report a young woman with ANKL showing central nervous system (CNS) invasion, who has been in complete remission for more than a year after allo-HCT following two courses of intravenous chemotherapy and several rounds of intrathecal chemotherapy. Intensive remission induction chemotherapy followed by conventional myeloablative allo-HCT is a promising approach for long-term remission in cases of this aggressive malignancy.

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© 2010 by The Japanese Society of Internal Medicine
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