Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Colon Cancer Arising in an Ulcer Scar due to Intestinal Behçet's Disease
Masayoshi YamadaHisakazu ShiroedaTomoe NomuraRanji HayashiKatsuaki SatoMikihiro TsutsumiTomiyasu Arisawa
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JOURNAL OPEN ACCESS

2011 Volume 50 Issue 5 Pages 429-432

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Abstract

Neoplasms rarely arise in the intestinal lesion of Behçet's disease. We present a 77-year-old man with Behçet's disease who developed colon cancer in the ileocecal region. Ileocecal resection was performed and pathological examination of the specimen revealed advanced colon carcinoma (pT3, N1, M0). The lesion was associated with destroyed tunica muscularis and severe fibrosis suggesting a transmural ulcer scar (Ul-IVs). The p53 gene mutation analysis of the tumor showed a heterozygous deletion. This case indicates there is a possibility that cancer may develop in intestinal lesions of patients with Behçet's disease as well as in those with other inflammatory bowel diseases.

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© 2011 by The Japanese Society of Internal Medicine
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