Isolated Mediastinal Myeloid Sarcoma Successfully Treated with Chemoradiotherapy Followed by Unrelated Allogeneic Stem Cell Transplantation

Jeong Mi Lee; Haa-Na Song; Yeojin Kang; Hosu Kim; Ji Hyun Min; Young Sun Suh; Jong-Hwa Ahn; Seung Hun Lee; Yun-Won Jo; Yun-Hong Cheon; Moon Jin Kim; Gyeong-Won Lee

doi:10.2169/internalmedicine.50.6125

CASE REPORTS

Isolated Mediastinal Myeloid Sarcoma Successfully Treated with Chemoradiotherapy Followed by Unrelated Allogeneic Stem Cell Transplantation

Jeong Mi Lee, Haa-Na Song, Yeojin Kang, Hosu Kim, Ji Hyun Min, Young Sun Suh, Jong-Hwa Ahn, Seung Hun Lee, Yun-Won Jo, Yun-Hong Cheon, Moon Jin Kim, Gyeong-Won Lee

Author information

Jeong Mi Lee
Division of Oncology and Hematology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Korea
Gyeongsang Institute of Health Science, Korea
Gyeongnam Regional Cancer Center, Korea
Haa-Na Song
Division of Oncology and Hematology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Korea
Gyeongsang Institute of Health Science, Korea
Gyeongnam Regional Cancer Center, Korea
Yeojin Kang
Division of Oncology and Hematology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Korea
Gyeongsang Institute of Health Science, Korea
Gyeongnam Regional Cancer Center, Korea
Hosu Kim
Division of Oncology and Hematology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Korea
Gyeongsang Institute of Health Science, Korea
Gyeongnam Regional Cancer Center, Korea
Ji Hyun Min
Division of Oncology and Hematology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Korea
Gyeongsang Institute of Health Science, Korea
Gyeongnam Regional Cancer Center, Korea
Young Sun Suh
Division of Oncology and Hematology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Korea
Gyeongsang Institute of Health Science, Korea
Gyeongnam Regional Cancer Center, Korea
Jong-Hwa Ahn
Division of Oncology and Hematology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Korea
Gyeongsang Institute of Health Science, Korea
Gyeongnam Regional Cancer Center, Korea
Seung Hun Lee
Division of Oncology and Hematology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Korea
Gyeongsang Institute of Health Science, Korea
Gyeongnam Regional Cancer Center, Korea
Yun-Won Jo
Division of Oncology and Hematology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Korea
Gyeongsang Institute of Health Science, Korea
Gyeongnam Regional Cancer Center, Korea
Yun-Hong Cheon
Division of Oncology and Hematology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Korea
Gyeongsang Institute of Health Science, Korea
Gyeongnam Regional Cancer Center, Korea
Moon Jin Kim
Division of Oncology and Hematology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Korea
Gyeongsang Institute of Health Science, Korea
Gyeongnam Regional Cancer Center, Korea
Gyeong-Won Lee
Division of Oncology and Hematology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Korea
Gyeongsang Institute of Health Science, Korea
Gyeongnam Regional Cancer Center, Korea

Keywords: mediastinum, myeloid sarcoma, radiotherapy, hematopoietic stem cell transplantation

JOURNAL OPEN ACCESS

2011 Volume 50 Issue 24 Pages 3003-3007

DOI https://doi.org/10.2169/internalmedicine.50.6125

Details

Abstract

A 22-year-old man was diagnosed with isolated mediastinal myeloid sarcoma which radiologically mimicked primary mediastinal lymphoma. Despite administration of standard remission induction chemotherapy with daunorubicin and cytarabine, and three cycles of intensive high-dose cytarabine-based consolidation, chemo-resistant hypermetabolic lesions were persistently detected in the highest mediastinum and in the supraclavicular area. However, complete remission and long-term survival were achieved by curative radiotherapy followed by unrelated allogeneic stem cell transplantation.

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