Combination Therapy with Adalimumab Plus Intensive Granulocyte and Monocyte Adsorptive Apheresis Induced Clinical Remission in a Crohn's Disease Patient with the Loss of Response to Scheduled Adalimumab Maintenance Therapy: A Case Report

Keiji Ozeki; Satoshi Tanida; Takashi Mizushima; Tsutomu Mizoshita; Hironobu Tsukamoto; Yoshikazu Hirata; Kenji Murakami; Takaya Shimura; Hiromi Kataoka; Takeshi Kamiya; Takashi Joh

doi:10.2169/internalmedicine.51.6801

CASE REPORTS

Combination Therapy with Adalimumab Plus Intensive Granulocyte and Monocyte Adsorptive Apheresis Induced Clinical Remission in a Crohn's Disease Patient with the Loss of Response to Scheduled Adalimumab Maintenance Therapy: A Case Report

Keiji Ozeki, Satoshi Tanida, Takashi Mizushima, Tsutomu Mizoshita, Hironobu Tsukamoto, Yoshikazu Hirata, Kenji Murakami, Takaya Shimura, Hiromi Kataoka, Takeshi Kamiya, Takashi Joh

Author information

Keiji Ozeki
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Satoshi Tanida
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Takashi Mizushima
Gifu Prefectural Tajimi Hospital, Japan
Tsutomu Mizoshita
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Hironobu Tsukamoto
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Yoshikazu Hirata
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Kenji Murakami
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Takaya Shimura
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Hiromi Kataoka
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Takeshi Kamiya
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Takashi Joh
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan

Keywords: refractory Crohn's disease, adalimumab, intensive granulocyte/monocyte adsorptive apheresis, anti-adalimumab antibody, clinical remission

JOURNAL OPEN ACCESS

2012 Volume 51 Issue 6 Pages 595-599

DOI https://doi.org/10.2169/internalmedicine.51.6801

Details

Abstract

A 21-year-old Caucasian man with a diagnosis of Crohn's disease (CD) at the age of 14 was admitted to our hospital due to CD flare-up while under scheduled adalimumab (ADA) maintenance therapy. His symptoms remained virtually unchanged following high dose corticosteroid therapy. Seven days later, combination therapy with ADA plus intensive granulocyte/monocyte adsorptive apheresis (GMA) was initiated, which induced clinical remission. Therefore, combination therapy with ADA plus intensive GMA appears to be an effective therapeutic option for patients with severe CD while under scheduled ADA maintenance therapy.

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