2007 Volume 54 Issue 2 Pages 95-102
Studies of the structure and function of Carbohydrate-Active enZymes (CAZymes) have made a great deal of progress over the last decade. The glycoside hydrolase (GH) family is a prominent class of CAZymes. There are more than 100 GH families, with wide variations in their 3 D structures (folds). This review focuses on the recently determined crystal structures of 4 GH families: GH42, GH57, GH54 and GH94. Possible evolutionary relationships between apparently unrelated GH families are discussed based on structural and mechanistic similarities.