Fasting Serum Apolipoprotein B-48 Can be a Marker of Postprandial Hyperlipidemia

Daisaku Masuda; Naohiko Sakai; Taizo Sugimoto; Rika Kitazume-Taneike; Taiji Yamashita; Ryota Kawase; Hajime Nakaoka; Miwako Inagaki; Kazuhiro Nakatani; Miyako Yuasa-Kawase; Kazumi Tsubakio-Yamamoto; Tohru Ohama; Yumiko Nakagawa-Toyama; Makoto Nishida; Masato Ishigami; Yoshiro Masuda; Akifumi Matsuyama; Issei Komuro; Shizuya Yamashita

doi:10.5551/jat.10470

Original Article

Fasting Serum Apolipoprotein B-48 Can be a Marker of Postprandial Hyperlipidemia

Daisaku Masuda, Naohiko Sakai, Taizo Sugimoto, Rika Kitazume-Taneike, Taiji Yamashita, Ryota Kawase, Hajime Nakaoka, Miwako Inagaki, Kazuhiro Nakatani, Miyako Yuasa-Kawase, Kazumi Tsubakio-Yamamoto, Tohru Ohama, Yumiko Nakagawa-Toyama, Makoto Nishida, Masato Ishigami, Yoshiro Masuda, Akifumi Matsuyama, Issei Komuro, Shizuya Yamashita

Author information

Daisaku Masuda
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Naohiko Sakai
Sakai Clinic.
Taizo Sugimoto
Sugimoto Clinic.
Rika Kitazume-Taneike
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Taiji Yamashita
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Ryota Kawase
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Hajime Nakaoka
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Miwako Inagaki
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Kazuhiro Nakatani
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Miyako Yuasa-Kawase
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Kazumi Tsubakio-Yamamoto
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Tohru Ohama
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Health Care Center, Osaka University.
Yumiko Nakagawa-Toyama
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Health Care Center, Osaka University.
Makoto Nishida
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Health Care Center, Osaka University.
Masato Ishigami
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine.
Yoshiro Masuda
Clinical Research Department, Pharmaceutical Division, Japan Tobacco Inc.
Akifumi Matsuyama
Department of Somatic Stem Cell Therapy, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation.
Issei Komuro
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Shizuya Yamashita
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.

Keywords: Apolipoproteins, Atherosclerosis, Chylomicrons, Postprandial hyperlipidemia, Remnants

JOURNAL OPEN ACCESS

2011 Volume 18 Issue 12 Pages 1062-1070

DOI https://doi.org/10.5551/jat.10470

View "Advance Publication" version (September 24, 2011).

Details

Abstract

Aim: Postprandial hyperlipidemia (PH) is thought to be caused by the impaired postprandial metabolism of triglycerides (TG)-rich lipoproteins in both endogenous and exogenous pathways; however, there is no consensus. It is difficult to estimate the presence of PH without performing a time-consuming oral fat loading (OFL) test, so postprandial lipoprotein metabolism was analyzed by measuring the postprandial levels of apolipoprotein (apo) B-48 and apo B-100, and the correlation between postprandial TG increase and fasting apoB-48 levels was assessed to establish a good marker of PH without performing an OFL test.
Methods: Ten male normolipidemic subjects were loaded with a high-fat (HF, 1045 kcal) or standard (ST, 566 kcal) meal, and the lipids, apolipoproteins and lipoprotein profiles were analyzed after each meal.
Results: TG, apo B-48, remnant-like particles (RLP)-cholesterol and RLP-TG levels were increased and their levels were significantly higher after intake of the HF meal than the ST meal; however, there was no postprandial increase in apo B-100 and LDL-C levels. Postprandial increases in TG levels of CM, VLDL, LDL and HDL were significantly higher after intake of the HF meal than the ST meal. Fasting apo B-48 levels were strongly correlated with the incremental area under the curve of TG after intake of the HF meal, but not the ST meal.
Conclusion: Postprandial TG increase was mainly due to increased CM and CM-R, but not VLDL. Measurement of fasting serum apo B-48 may be a simple and useful method for assessment of the existence of PH.

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