Polymorphisms in Four Genes Related to Triglyceride and HDL-cholesterol Levels in the General Japanese Population in 2000

Hidenori Arai; Akira Yamamoto; Yuji Matsuzawa; Yasushi Saito; Nobuhiro Yamada; Shinichi Oikawa; Hiroshi Mabuchi; Tamio Teramoto; Jun Sasaki; Noriaki Nakaya; Hiroshige Itakura; Yuichi Ishikawa; Yasuyoshi Ouchi; Hiroshi Horibe; Tohru Egashira; Hiroaki Hattori; Nobuo Shirahashi; Toru Kita

doi:10.5551/jat.12.240

Original Article

Polymorphisms in Four Genes Related to Triglyceride and HDL-cholesterol Levels in the General Japanese Population in 2000

Hidenori Arai, Akira Yamamoto, Yuji Matsuzawa, Yasushi Saito, Nobuhiro Yamada, Shinichi Oikawa, Hiroshi Mabuchi, Tamio Teramoto, Jun Sasaki, Noriaki Nakaya, Hiroshige Itakura, Yuichi Ishikawa, Yasuyoshi Ouchi, Hiroshi Horibe, Tohru Egashira, Hiroaki Hattori, Nobuo Shirahashi, Toru Kita

Author information

Hidenori Arai
Department of Geriatric Medicine, Kyoto University School of Medicine, Kyoto, Japan.
Akira Yamamoto
National Cardiovascular Center, Osaka, Japan.
Yuji Matsuzawa
Department of Internal Medicine, Osaka University, Osaka, Japan.
Yasushi Saito
Department of Internal Medicine, Chiba University, Chiba, Japan.
Nobuhiro Yamada
Department of Internal Medicine, Tsukuba University, Ibaraki, Japan.
Shinichi Oikawa
Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Hiroshi Mabuchi
Department of Internal Medicine, Kanazawa University, Ishikawa, Japan.
Tamio Teramoto
Department of Internal Medicine, Teikyo University, Tokyo, Japan.
Jun Sasaki
International University of Health and Welfare, Tochigi, Japan.
Noriaki Nakaya
Fussa Hospital, Tokyo, Japan.
Hiroshige Itakura
Ibaraki Christian University, Ibaraki, Japan.
Yuichi Ishikawa
Faculty of Health Sciences, Kobe University, Hyogo, Japan.
Yasuyoshi Ouchi
Department of Geriatric Medicine, University of Tokyo, Tokyo, Japan.
Hiroshi Horibe
Keisen Clinic, Tokyo, Japan.
Tohru Egashira
Department of Advanced Technology and Development, BML, Inc., Tokyo, Japan.
Hiroaki Hattori
Department of Advanced Technology and Development, BML, Inc., Tokyo, Japan.
Nobuo Shirahashi
Osaka City University Medical School, Osaka, Japan.
Toru Kita
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Keywords: Hyperlipidemia, Polymorphism, Cholesterol ester transfer protein, Lipoprotein lipase, Triglyceride lipase, Apolipoprotein CIII

JOURNAL OPEN ACCESS

2005 Volume 12 Issue 5 Pages 240-250

DOI https://doi.org/10.5551/jat.12.240

Details

Abstract

We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (LIPC), and apolipoprotein CIII (APOC3), and studied 2267 individuals randomly selected from the participants of Serum Lipid Survey 2000. There was a significant association of CETP polymorphism (D442G, Int14 +1 G → A, and TaqIB), LPL polymorphism (S447X), and LIPC polymorphism (−514 → CT) with HDL-cholesterol levels. We also found a significant association of LPL polymorphism (S447X) and APOC3 polymorphism (SstI) with triglyceride levels. This is the largest database showing the association of common genetic variants in lipid metabolism with serum lipid levels in the general Japanese population. Further study is necessary to elucidate the role of these gene polymorphisms in cardiovascular events.

Corresponding author

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