In-air microparticle induced X-ray emission analysis of particles in interstitial pneumonia lung tissue obtained by transbronchial biopsy

Yasuo Shimizu; Shinichi Matsuzaki; Takahiro Satoh; Masashi Koka; Akihito Yokoyama; Takeru Ohkubo; Yasuyuki Ishii; Tomihiro Kamiya; Makoto Fueki; Masatomo Mori; Kunio Dobashi

doi:10.3164/jcbn.10-127

Original Articles

In-air microparticle induced X-ray emission analysis of particles in interstitial pneumonia lung tissue obtained by transbronchial biopsy

Yasuo Shimizu, Shinichi Matsuzaki, Takahiro Satoh, Masashi Koka, Akihito Yokoyama, Takeru Ohkubo, Yasuyuki Ishii, Tomihiro Kamiya, Makoto Fueki, Masatomo Mori, Kunio Dobashi

Author information

Yasuo Shimizu
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
Jobu Hospital for Respiratory Disease
Shinichi Matsuzaki
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
Takahiro Satoh
Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Institute
Masashi Koka
Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Institute
Akihito Yokoyama
Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Institute
Takeru Ohkubo
Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Institute
Yasuyuki Ishii
Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Institute
Tomihiro Kamiya
Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Institute
Makoto Fueki
Jobu Hospital for Respiratory Disease
Masatomo Mori
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
Kunio Dobashi
Gunma University Faculty of Health Science

Keywords: transbronchial biopsy, in-air micro-PIXE analysis, elemental analysis, particles, interstitial pneumonia

JOURNAL FREE ACCESS

2011 Volume 49 Issue 2 Pages 125-130

DOI https://doi.org/10.3164/jcbn.10-127

View "Advance Publication" version (July 13, 2011).

Details

Abstract

Interstitial pneumonia develops in association with inhaled particles. In-air microparticle induced X-ray emission (in-air micro) analysis was previously employed to assess the spatial distribution and content of particles in surgical lung biopsy specimens. The aim of this study was to assess the efficacy of in-air micro-analysis for transbronchial lung biopsy specimens in patients with or without occupational exposure. The elements composing lung particles and their locations could be identified by in-air micro-analysis. Silicon was the major component of particles. Quantitative analysis revealed that the elements composing lung particles varied between patients. In a patient with suspected nickel exposure, aluminium, vanadium, and calcium were detected, but was not detected. In a patient without a work history (housewife), various elements were detected. In-air micro-analysis was useful for assessing the spatial distribution and content of particles in specimens from patients. Occupational exposure was not necessarily associated with deposition of particles in the lungs. Therefore, in the diagnosis of, elemental analysis of specimens by in-air micro-analysis could be useful for assessing exposure to particles objectively.

Corresponding author

Register with J-STAGE for free!