Beneficial Effect of Food Substitute Containing L-Arginine, ω-3 Poly Unsaturated Fatty Acid, and Ribonucleic Acid in Preventing or Improving Metabolic Syndrome: A Study in 15 Overweight Patients and a Study of Fatty Acid Metabolism in Animals

Kenichi Watanabe; Wawaimuli Arozal; Hiroko Tanaka; Meilei Ma; Susumu Satoh; Punniyakoti T. Veeraveedu; Takashi Kobayashi; Hiroshi Oyama; Yoshiko Sakaguchi

doi:10.3164/jcbn.08-241

Original Articles

Beneficial Effect of Food Substitute Containing L-Arginine, ω-3 Poly Unsaturated Fatty Acid, and Ribonucleic Acid in Preventing or Improving Metabolic Syndrome: A Study in 15 Overweight Patients and a Study of Fatty Acid Metabolism in Animals

Kenichi Watanabe, Wawaimuli Arozal, Hiroko Tanaka, Meilei Ma, Susumu Satoh, Punniyakoti T. Veeraveedu, Takashi Kobayashi, Hiroshi Oyama, Yoshiko Sakaguchi

Author information

Kenichi Watanabe
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
Wawaimuli Arozal
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
Hiroko Tanaka
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
Meilei Ma
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
Susumu Satoh
BBK Bio Corporation
Punniyakoti T. Veeraveedu
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
Takashi Kobayashi
Niigata Association of Occupational Health, Inc.
Department of Clinical Information Engineering, Health Services Sciences, School of Public Health Graduate School of Medicine, University of Tokyo
Hiroshi Oyama
Department of Clinical Information Engineering, Health Services Sciences, School of Public Health Graduate School of Medicine, University of Tokyo
Yoshiko Sakaguchi
Niigata Bio-Research Park, Inc.

Keywords: L-arginine, ω-3 poly unsaturated fatty acid, ribonucleic acid, metabolic syndrome, fatty acid metabolism

JOURNAL FREE ACCESS

2009 Volume 44 Issue 3 Pages 266-274

DOI https://doi.org/10.3164/jcbn.08-241

Details

Abstract

This study was conducted to investigate whether or not a food substitute (Dr. BAANs^®) containing three bioactive components L-arginine, ω-3 polyunsaturated fatty acid, and ribonucleic acid, supplied orally to 15 overweight patients, may have efficacy to prevent or improve the metabolic syndrome of these patients. To provide supporting data for this clinical study, the in vivo fatty acid metabolism of obese mice was analyzed using ¹²⁵I labeled 15-(p-iodophenyl)-9-methylpentadecanoic acid (9MPA) in the tissues’ lipid pool. After 3 months of intervention, the results showed that there were improvements observed in liver functions, lipid profiles and metabolic syndrome marker. Significant differences were also found in the values of blood pressure, body weight, percentage of body fat, and body mass index. In the animal study, the tissue uptake of ¹²⁵I-9MPA at 10 min after injection was higher in obese mice than in the control mice and the treatment with Dr. BAANs^® in obese mice decreased the uptake significantly. The final product metabolite of p-iodophenylacetic acid in obese mice was increased significantly by the treatment. In conclusion, this food substitute may have a beneficial effect for the prevention or improvement of metabolic syndrome.

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