Department of Preventive Medicine, Nagoya University Graduate School of Medicine
Department of Preventive Medicine, Nagoya University Graduate School of Medicine
Department of Preventive Medicine, Nagoya University Graduate School of Medicine
Department of Preventive Medicine, Nagoya University Graduate School of Medicine
Department of Preventive Medicine, Nagoya University Graduate School of Medicine
Department of Preventive Medicine, Nagoya University Graduate School of Medicine
Department of Preventive Medicine, Nagoya University Graduate School of Medicine
Department of Preventive Medicine, Nagoya University Graduate School of Medicine
Department of Preventive Medicine, Nagoya University Graduate School of Medicine
Seirei Social Welfare Community
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Science
Aichi Cancer Center Research Institute
Department of Preventive Medicine, Faculty of Medicine, Saga University
Laboratory of Exercise Physiology, Faculty of Sports and Health Science, Fukuoka University
Department of Preventive Medicine, Faculty of Medicine, Saga University
Department of Preventive Medicine, Faculty of Medicine, Saga University
Department of Preventive Medicine, Faculty of Medicine, Saga University
Department of Preventive Medicine, Faculty of Medicine, Saga University
Department of Preventive Medicine, Faculty of Medicine, Saga University
Asakura Health Welfare Environment Office, Fukuoka Prefectural Government
Department of Preventive Medicine, Faculty of Medicine, Saga University
Division of International Health and Nursing, Faculty of Medicine, Saga University
Department of Health Science, Shiga University of Medical Science
Department of Health Science, Shiga University of Medical Science
Department of Health Science, Shiga University of Medical Science
Department of Health Science, Shiga University of Medical Science
Department of Health Science, Shiga University of Medical Science
Department of Health Science, Shiga University of Medical Science Lifestyle-Related Disease Prevention Center, Shiga University of Medical Science
Lifestyle-Related Disease Prevention Center, Shiga University of Medical Science
Department of Cardiovascular Epidemiology, Kyoto Women’s University
Department of Public Health, Nagoya City University Graduate School of Medical Sciences
Department of Public Health, Nagoya City University Graduate School of Medical Sciences
Department of Public Health, Nagoya City University Graduate School of Medical Sciences
Department of Public Health, Nagoya City University Graduate School of Medical Sciences
Department of Public Health, Nagoya City University Graduate School of Medical Sciences
Department of Public Health, Nagoya City University Graduate School of Medical Sciences
Department of Public Health, Nagoya City University Graduate School of Medical Sciences
Public Health Center, Okazaki City Medical Association
Public Health Center, Okazaki City Medical Association
Department of Public Health, Nagoya City University Graduate School of Medical Sciences
Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
Division of Cancer Registry, Prevention and Epidemiology, Chiba Cancer Center
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
Unit for Liveable Cities, Graduate School of Medicine, Kyoto University
Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
2011 Volume 21 Issue 3 Pages 223-235
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Background: Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene–environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005.
Methods: We initiated a cross-sectional study to examine associations of genotypes with lifestyle and clinical factors, as assessed by questionnaires and medical examinations. The 4519 subjects were selected from among participants in the J-MICC Study in 10 areas throughout Japan. In total, 108 polymorphisms were chosen and genotyped using the Invader assay.
Results: The study group comprised 2124 men and 2395 women with a mean age of 55.8 ± 8.9 years (range, 35–69 years) at baseline. Among the 108 polymorphisms examined, 4 were not polymorphic in our study population. Among the remaining 104 polymorphisms, most variations were common (minor allele frequency ≥0.05 for 96 polymorphisms). The allele frequencies in this population were comparable with those in the HapMap-JPT data set for 45 Japanese from Tokyo. Only 5 of 88 polymorphisms showed allele-frequency differences greater than 0.1. Of the 108 polymorphisms, 32 showed a highly significant difference in minor allele frequency among the study areas (P < 0.001).
Conclusions: This comprehensive data collection on lifestyle and clinical factors will be useful for elucidating gene–environment interactions. In addition, it is likely to be an informative reference tool, as free access to genotype data for a large Japanese population is not readily available.