Journal of Epidemiology
Online ISSN : 1349-9092
Print ISSN : 0917-5040
ISSN-L : 0917-5040
Study Profile
Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors: A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study
Kenji WakaiNobuyuki HamajimaRieko OkadaMariko NaitoEmi MoritaAsahi HishidaSayo KawaiKazuko NishioGuang YinYatami AsaiKeitaro MatsuoSatoyo HosonoHidemi ItoMiki WatanabeTakakazu KawaseTakeshi SuzukiKazuo TajimaKeitaro TanakaYasuki HigakiMegumi HaraTakeshi ImaizumiNaoto TaguchiKazuyo NakamuraHinako NanriTatsuhiko SakamotoMikako HoritaKoichi ShinchiYoshikuni KitaTanvir Chowdhury TurinNahid RumanaKenji MatsuiKatsuyuki MiuraHirotsugu UeshimaNaoyuki TakashimaYasuyuki NakamuraSadao SuzukiRyosuke AndoAkihiro HosonoNahomi ImaedaKiyoshi ShibataChiho GotoNami HattoriMitsuru FukatsuTamaki YamadaShinkan TokudomeToshiro TakezakiHideshi NiimuraKazuyo HirasadaAkihiko NakamuraMasaya TateboShin OgawaNoriko TsunematsuShirabe ChibaHaruo MikamiSuminori KonoKeizo OhnakaRyoichi TakayanagiYoshiyuki WatanabeEtsuko OzakiMasako ShigetaNagato KuriyamaAya YoshikawaDaisuke MatsuiIsao WatanabeKaoru InoueKotaro OzasaSatoko MitaniKokichi ArisawaHirokazu UemuraMineyoshi HiyoshiHidenobu TakamiMiwa YamaguchiMariko NakamotoHideo TakedaMichiaki KuboHideo Tanaka
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2011 Volume 21 Issue 3 Pages 223-235

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Abstract

Background: Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene–environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005.
Methods: We initiated a cross-sectional study to examine associations of genotypes with lifestyle and clinical factors, as assessed by questionnaires and medical examinations. The 4519 subjects were selected from among participants in the J-MICC Study in 10 areas throughout Japan. In total, 108 polymorphisms were chosen and genotyped using the Invader assay.
Results: The study group comprised 2124 men and 2395 women with a mean age of 55.8 ± 8.9 years (range, 35–69 years) at baseline. Among the 108 polymorphisms examined, 4 were not polymorphic in our study population. Among the remaining 104 polymorphisms, most variations were common (minor allele frequency ≥0.05 for 96 polymorphisms). The allele frequencies in this population were comparable with those in the HapMap-JPT data set for 45 Japanese from Tokyo. Only 5 of 88 polymorphisms showed allele-frequency differences greater than 0.1. Of the 108 polymorphisms, 32 showed a highly significant difference in minor allele frequency among the study areas (P < 0.001).
Conclusions: This comprehensive data collection on lifestyle and clinical factors will be useful for elucidating gene–environment interactions. In addition, it is likely to be an informative reference tool, as free access to genotype data for a large Japanese population is not readily available.

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© 2011 by the Japan Epidemiological Association
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