Xanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Kappa B During Hepatic Ischemia in Rats

Nobuaki Matsui; Ikuko Satsuki; Yuka Morita; Keiichi Inaizumi; Kazumi Kasajima; Reiko Kanoh; Nobuyuki Fukuishi; Masaaki Akagi

doi:10.1254/jjp.84.363

Short Communication

Xanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Kappa B During Hepatic Ischemia in Rats

Nobuaki Matsui, Ikuko Satsuki, Yuka Morita, Keiichi Inaizumi, Kazumi Kasajima, Reiko Kanoh, Nobuyuki Fukuishi, Masaaki Akagi

Author information

Nobuaki Matsui
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima city, Tokushima 770-8514, Japan
Ikuko Satsuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima city, Tokushima 770-8514, Japan
Yuka Morita
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima city, Tokushima 770-8514, Japan
Keiichi Inaizumi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima city, Tokushima 770-8514, Japan
Kazumi Kasajima
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima city, Tokushima 770-8514, Japan
Reiko Kanoh
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima city, Tokushima 770-8514, Japan
Nobuyuki Fukuishi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima city, Tokushima 770-8514, Japan
Masaaki Akagi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima city, Tokushima 770-8514, Japan

Keywords: Xanthine oxidase, Nuclear factor kappa B, Reactive oxygen species

JOURNAL FREE ACCESS

2000 Volume 84 Issue 3 Pages 363-366

DOI https://doi.org/10.1254/jjp.84.363

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Abstract

The present study was carried out to elucidate the relationship between the generation of reactive oxygen species (ROS) and an activation of nuclear factor (NF) kappa B in a hepatic ischemia-reperfusion model. During the ischemic period, the contents of xanthine oxidase (XOD) metabolites and thiobarbituric acid-reactive substances were significantly increased, and NF-kappa B was activated in the liver of rats. The activation of NF-kappa B was inhibited by pretreatment of allopurinol (10-100mg/kg, i.p.) in a dose-dependent manner. In conclusion, this suggests that the XOD-derived ROS may activate NF-kappa B during ischemia.

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