Protein Kinase C Inhibitors Attenuate Protective Effect of High Glucose against Hypoxic Injury in H9c2 Cardiac Cells

Chang-Hyun Moon; Yi-Sook Jung; Min Hwa Kim; Rhan Mi Park; Soo Hwan Lee; Eun Joo Baik

doi:10.2170/jjphysiol.50.645

The Japanese Journal of Physiology

Print ISSN : 0021-521X

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Protein Kinase C Inhibitors Attenuate Protective Effect of High Glucose against Hypoxic Injury in H9c2 Cardiac Cells

Chang-Hyun Moon, Yi-Sook Jung, Min Hwa Kim, Rhan Mi Park, Soo Hwan Lee, Eun Joo Baik

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Keywords: high glucose, cardioprotection, PKC

JOURNAL FREE ACCESS

2000 Volume 50 Issue 6 Pages 645-649

DOI https://doi.org/10.2170/jjphysiol.50.645

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Abstract

In this study, we demonstrated that PKC inhibitors significantly attenuated the cardioprotective effect produced by high-glucose (22 mM) treatment for 48 h against hypoxic injury in H9c2 cardiac cells. PKC activators mimicked the cardioprotective effect of high glucose. These results suggest a possible role of PKC activation in high-glucose-induced protection.

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