Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K) / Akt Pathway

Shuichiro Yano; Saori Morino-Koga; Tatsuya Kondo; Mary Ann Suico; Tomoaki Koga; Yuichiro Shimauchi; Shingo Matsuyama; Tsuyoshi Shuto; Takashi Sato; Eiichi Araki; Hirofumi Kai

doi:10.1254/jphs.10185SC

Short Communications

Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K) / Akt Pathway

Shuichiro Yano, Saori Morino-Koga, Tatsuya Kondo, Mary Ann Suico, Tomoaki Koga, Yuichiro Shimauchi, Shingo Matsuyama, Tsuyoshi Shuto, Takashi Sato, Eiichi Araki, Hirofumi Kai

Author information

Shuichiro Yano
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate Regulation Research and Education Unit”, Kumamoto University, Japan
Saori Morino-Koga
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate Regulation Research and Education Unit”, Kumamoto University, Japan
Tatsuya Kondo
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
Mary Ann Suico
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate Regulation Research and Education Unit”, Kumamoto University, Japan
Tomoaki Koga
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate Regulation Research and Education Unit”, Kumamoto University, Japan
Yuichiro Shimauchi
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate Regulation Research and Education Unit”, Kumamoto University, Japan
Shingo Matsuyama
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate Regulation Research and Education Unit”, Kumamoto University, Japan
Tsuyoshi Shuto
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate Regulation Research and Education Unit”, Kumamoto University, Japan
Takashi Sato
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate Regulation Research and Education Unit”, Kumamoto University, Japan
Eiichi Araki
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
Hirofumi Kai
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate Regulation Research and Education Unit”, Kumamoto University, Japan

Keywords: mild electrical stimulation, phosphatidylinositol-3-OH kinase (PI-3K) / Akt, glucose uptake

JOURNAL FREE ACCESS

2011 Volume 115 Issue 1 Pages 94-98

DOI https://doi.org/10.1254/jphs.10185SC

View "Advance Publication" version (December 18, 2010).

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Abstract

Activation of Akt by insulin is transmitted via phosphatidylinositol-3-OH kinase (PI-3K) and enhances glucose uptake. The PI-3K/Akt signaling is diminished in insulin resistance. Thus, approaches that activate PI-3K/Akt signaling leading to improved glucose uptake may ameliorate hyperglycemia. Here we showed that low-intensity electrical current or mild electrical stimulation (MES) activated the PI-3K/Akt signaling and increased the glucose uptake in rat skeletal muscle (L6) cells. The glucose uptake enhanced by MES in muscle cells, the major cells involved in glucose disposal, suggests MES may have a possible beneficial effect on hyperglycemia.

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