Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
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Neuroprotective Effects of Quercetin and Rutin on Spatial Memory Impairment in an 8-Arm Radial Maze Task and Neuronal Death Induced by Repeated Cerebral Ischemia in Rats
Fengling PuKenichi MishimaKeiichi IrieKyouko MotohashiYurika TanakaKensuke OritoTakashi EgawaYoshihisa KitamuraNobuaki EgashiraKatsunori IwasakiMichihiro Fujiwara
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2007 Volume 104 Issue 4 Pages 329-334

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Abstract

In order to determine the differential effects of flavonoids on cerebral ischemia, we investigated the effects of (−)-epigallocatechin gallate (EGCG), catechin, rutin, and quercetin on spatial memory impairment and neuronal death induced by repeated cerebral ischemia in rats. Both rutin and quercetin (50 mg/kg × 2) improved spatial memory impairment in the 8-arm radial maze task and neuronal death in the hippocampal CA1 area; however, catechin (200 mg/kg × 2) and EGCG (50 mg/kg × 1) did not. Administration of EGCG (50 mg/kg × 2) resulted in a high mortality rate. These results suggest that in this repeated cerebral ischemia model, the 4-oxo group and the 2,3-double bond in the C ring of rutin and quercetin are related to their neuroprotective action.

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© The Japanese Pharmacological Society 2007
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