Journal of Smooth Muscle Research
Online ISSN : 1884-8796
Print ISSN : 0916-8737
ISSN-L : 0916-8737
Original
Effects of aging on α1-adrenoceptor mechanisms in the isolated mouse aortic preparation
Yoshio TanakaMidori FunabikiHiromi MichikawaKatsuo Koike
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JOURNAL FREE ACCESS

2006 Volume 42 Issue 4 Pages 131-138

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Abstract

The effects of aging on α1-adrenoceptor (α1-AR)-mediated contractile response in endothelium-removed aortic preparations isolated from 5- to 40-week-old (5-, 6-, 8-, 10-, 20-, 40-weeks) mice were studied in the presence of propranolol. The potency of noradrenaline, estimated as its pD2 value, increased with age from 5- to 10-weeks, but decreased thereafter with age from 10- to 40-weeks. However, the affinity of prazosin (pA2 value) did not change with aging. These results suggest that age-related change in noradrenaline potency is not attributable to the change of drug affinity to α1-ARs, but is possibly due to drug affinity-unrelated factors such as change of the reserve of α1-ARs.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc/4.0/deed.ja
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