The reduction of arterial tension produced by stevioside is dependent on nitric oxide synthase activity when the endothelium is intact

Elaine Campana Sanches Bornia; Valéria do Amaral; Roberto Barbosa Bazotte; Wilson Alves-Do-Prado

doi:10.1540/jsmr.44.1

Original

The reduction of arterial tension produced by stevioside is dependent on nitric oxide synthase activity when the endothelium is intact

Elaine Campana Sanches Bornia, Valéria do Amaral, Roberto Barbosa Bazotte, Wilson Alves-Do-Prado

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Keywords: Stevia rebaudiana (Bert) Bertoni, Compositae, stevioside, nitric oxide, aortic ring

JOURNAL FREE ACCESS

2008 Volume 44 Issue 1 Pages 1-8

DOI https://doi.org/10.1540/jsmr.44.1

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Abstract

In endothelium-intact rat aortic ring preparations pre-contracted with norepinephrine or KCl, N^G-nitro L-arginine (L-NOARG, 0.1 mM) and 1H-[1,2,4] oxidiazolo [4,3-a] quinoxalin-1-one (ODQ, 10 μM) antagonized the reduction of the vascular tone induced by stevioside, but this antagonism did not occur when the experiment was performed with endothelium-denuded aortic rings. The data indicates that the vasodilatation produced by stevioside is dependent on nitric oxide synthase and guanylate cyclase activities when the endothelium is not damaged.

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