The effect of omeprazole on gastric myoelectrical activity and emptying

Takeshi Kamiya; Michiko Shikano; Mamoru Tanaka; Hironobu Tsukamoto; Masahide Ebi; Yoshikazu Hirata; Takashi Mizushima; Kenji Murakami; Takaya Shimura; Tsutomu Mizoshita; Yoshinori Mori; Satoshi Tanida; Takashi Kato; Kenro Imaeda; Hiromi Kataoka; Takashi Joh

doi:10.1540/jsmr.47.79

Original

The effect of omeprazole on gastric myoelectrical activity and emptying

Takeshi Kamiya, Michiko Shikano, Mamoru Tanaka, Hironobu Tsukamoto, Masahide Ebi, Yoshikazu Hirata, Takashi Mizushima, Kenji Murakami, Takaya Shimura, Tsutomu Mizoshita, Yoshinori Mori, Satoshi Tanida, Takashi Kato, Kenro Imaeda, Hiromi Kataoka, Takashi Joh

Author information

Takeshi Kamiya
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Michiko Shikano
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Mamoru Tanaka
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Hironobu Tsukamoto
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Masahide Ebi
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Yoshikazu Hirata
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Takashi Mizushima
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Kenji Murakami
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Takaya Shimura
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Tsutomu Mizoshita
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Yoshinori Mori
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Satoshi Tanida
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Takashi Kato
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Kenro Imaeda
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Hiromi Kataoka
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Takashi Joh
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan

Keywords: omeprazole, functional dyspepsia, electrogastrography, gastric emptying

JOURNAL FREE ACCESS

2011 Volume 47 Issue 3+4 Pages 79-87

DOI https://doi.org/10.1540/jsmr.47.79

Details

Abstract

Omeprazole, a proton pump inhibitor, is widely used for the treatment of patients with peptic ulcer, gastroesophageal reflux disease and functional dyspepsia (FD), although some studies have demonstrated that omeprazole delays gastric emptying. The purpose of this study was to investigate the efficacy of omeprazole on gastric motility including gastric myoelectrical activity and gastric emptying. This study was performed on 12 healthy volunteers. Gastric motility was evaluated with cutaneously recorded electrogastrography (EGG) and gastric emptying of semi-solid meals using the ¹³C-acetic acid breath test. EGG and gastric emptying were measured before and after treatment with 20 mg omeprazole orally for 7 days. In the fasting state, the percentage of EGG normogastria increased significantly compared to the baseline. No significant changes were observed in other EGG parameters including the percentage of tachygastria and bradygastria in both fasting and postprandial states, and the power ratios between both before and after ingestion of omeprazole. In addition, administrated omeprazole did not show any significant differences in the gastric emptying parameters such as the half emptying time. We conclude that administration of omeprazole did not affect gastric motility but improved gastric myoelectrical activity. These effects of omeprazole may be one of the mechanisms involved in its efficacy in relieving dyspeptic symptoms in FD patients.

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