The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Letter
Cyclin D1/cdk4, estrogen receptors α and β, in N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis: immunohistochemical study
Masaya MotohashiShin WakuiTomoko MutoYoshihiko SuzukiMasaru ShiraiHiroyuki TakahashiHiroshi Hano
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2011 Volume 36 Issue 3 Pages 373-378

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Abstract

Hyperproliferative cell growth due to cyclin D1/cdk4, marker of cellular proliferation, is considered to be regulated by the expression of estrogen receptors (ERs). We investigated the immunohistochemical expression of cyclin D1/cdk4 and ERs in N-methyl-N’-nitro-N-nitrosoguanidine (MNNG)-induced rat gastric carcinogenesis. The gastric cancer incidence and expression of cyclin D1/ckd4 in gastric carcinogenesis were significantly higher in males than females. Although the ERα expression index was similar in both sexes, the ERβ expression in preneoplastic hyperplastic lesions as well as gastric cancers was significantly higher in females than in males. The present study revealed a gender difference in MNNG-induced rat gastric carcinogenesis that seemed to involve the sex difference in cyclin D1/cdk4 expression, and ERβ expression became evident at the preneoplastic promotion stage in gastric carcinogenesis.

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© 2011 The Japanese Society of Toxicology
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