Molecular Characterization of the Hemagglutinin and Neuraminidase Genes of H5N1 Influenza A Viruses Isolated from Poultry in Vietnam from 2004 to 2005

Yukiko MURAMOTO; Thi Quynh Mai LE; Lien Song PHUONG; Tung NGUYEN; Thu Ha NGUYEN; Yuko SAKAI-TAGAWA; Kiyoko IWATSUKI-HORIMOTO; Taisuke HORIMOTO; Hiroshi KIDA; Yoshihiro KAWAOKA

doi:10.1292/jvms.68.527

NOTE

Molecular Characterization of the Hemagglutinin and Neuraminidase Genes of H5N1 Influenza A Viruses Isolated from Poultry in Vietnam from 2004 to 2005

Yukiko MURAMOTO, Thi Quynh Mai LE, Lien Song PHUONG, Tung NGUYEN, Thu Ha NGUYEN, Yuko SAKAI-TAGAWA, Kiyoko IWATSUKI-HORIMOTO, Taisuke HORIMOTO, Hiroshi KIDA, Yoshihiro KAWAOKA

Author information

Yukiko MURAMOTO
International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Thi Quynh Mai LE
National Institute of Hygiene and Epidemiology
Lien Song PHUONG
National Center for Veterinary Diagnosis, Department of Animal Health, Ministry of Agriculture and Rural Development
Tung NGUYEN
National Center for Veterinary Diagnosis, Department of Animal Health, Ministry of Agriculture and Rural Development
Thu Ha NGUYEN
National Center for Veterinary Diagnosis, Department of Animal Health, Ministry of Agriculture and Rural Development
Yuko SAKAI-TAGAWA
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Kiyoko IWATSUKI-HORIMOTO
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Taisuke HORIMOTO
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Hiroshi KIDA
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
Yoshihiro KAWAOKA
International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison

Keywords: H5N1 avian influenza virus, hemagglutinin, neuraminidase

JOURNAL FREE ACCESS

2006 Volume 68 Issue 5 Pages 527-531

DOI https://doi.org/10.1292/jvms.68.527

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Abstract

Highly pathogenic H5N1 avian influenza A viruses have been spreading among domestic poultry, wild aquatic birds, and humans in many Asian countries since 2003. The largest number of patients, to date, infected with the H5N1 viruses are in Vietnam, where these viruses continue to cause outbreaks in domestic poultry. Here, we molecularly characterized the hemagglutinin and neuraminidase genes of nine H5N1 viruses isolated between January 2004 and August 2005 from domestic poultry in Vietnam. We found that several groups of highly pathogenic H5N1 avian influenza viruses are circulating among these birds, which suggests that H5N1 viruses of different lineages have been introduced into Vietnam multiple times.

Corresponding author

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