Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
NOTE
Ceftiofur Distribution in Plasma and Tissues Following Subcutaneously Administration in Ducks
Hee Sik CHUNGWon Chul JUNGDong Hyeok KIMJeong Ju LIMHo Yeong SONSuk KIMHu Jang LEE
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Keywords: ceftiofur, duck, HPLC
JOURNAL FREE ACCESS

2007 Volume 69 Issue 10 Pages 1081-1085

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Abstract

A study was performed to determine the residues in blood and edible tissues of healthy ducks (25 days old, mean body weight 1.0 ± 0.13 kg) after subcutaneous administration of ceftiofur sodium at a dose rate of 2 mg/kg body weight (Group I) and 4 mg/kg body weight (Group II). Blood, muscle, liver, kidney, and fat samples were collected from all of ducks on the 1st, 2nd, 3rd, 4th, and 5th day after treatment of drug, and ceftiofur was analyzed with a high-performance liquid chromatography (HPLC) assay with results reported as ceftiofur-free acid equivalent (CFAE). To study the spiked recovery, blank plasma and tissues were spiked with two different concentrations of ceftiofur sodium (0.1, 0.5 μg/g). Average recovery values for all samples ranged from 70.3 to 87.3%. In the group I, desfuroylceftiofur acetamide (DCA) was not detected in all of plasma, muscle, liver, and fat tissues on the 1st day after treatment. But, kidney samples on the 1st day were detected DCA (0.059 ± 0.01 μg CFAE/g tissue). On the 2nd day of post-treatment, the concentrations of DCA in all tissues were lower than the detection limit, 0.05 μg CFAE /g tissue. In the group II on the 1st day after treatment, the concentration of DCA was 0.124 ± 0.06 μg CFAE/g tissue, 0.103 ± 0.03 μg CFAE/g tissue, and 0.071 ± 0.010 μg CFAE/g tissue in plasma, kidney, and muscle samples, respectively. On the 2nd day after treatment of ceftiofur, the concentrations of DCA in all tissues were lower than 0.05 μg CFAE/g tissue. According to our results, the concentrations of DCA on the 1st day after treatment with 2 mg/kg body weight were below 0.05 μg CFAE/g tissue equivalent in all tissues except for kidney. On the 2nd day after administration at the dose of 4 mg/kg body weight, no DCA was also detected in all of the tissues although DCA was detected in all samples on the 1st day.

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© 2007 by the Japanese Society of Veterinary Science

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https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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