Magnetic Resonance in Medical Sciences
Online ISSN : 1880-2206
Print ISSN : 1347-3182
ISSN-L : 1347-3182
Case Report
Transient Splenial Lesion of the Corpus Callosum after Acute Withdrawal of Antiepileptic Drug: A Case Report
Kazuhiro HONDA, Jin NISHIMIYA, Hideki SATO, Maki MUNAKATA, Masaki KAMADA, Akihide IWAMURA, Hideaki NEMOTO, Takashi SAKAMOTO, Tatsuhiko YUASA
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Keywords: splenium, corpus callosum, diffusion-weighted image, carbamazepine, diabetes insipidus
JOURNAL OPEN ACCESS

2006 Volume 5 Issue 4 Pages 211-215

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Abstract

Transient lesions at the splenium of the corpus callosum (SCC) have been reported after withdrawal of specific antiepileptic drugs (AED), though the pathophysiology of the lesions remains unclear. We examined and treated a schizophrenic patient who developed a transient SCC lesion after withdrawal of the AED, carbamazepine. Interestingly, the SCC lesion was accompanied by the onset of diabetes insipidus, a state of arginine-vasopressin (AVP) insufficiency. Because carbamazepine is shown to potentiate the effect of AVP, our case suggests that an insufficiency of AVP followed by withdrawal of AED could contribute to the pathogenesis of a transient SCC lesion.

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© 2006 by Japanese Society for Magnetic Resonance in Medicine
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