We report a case of chronic osteomyelitis of the left tibia treated by β-tricalcium phosphate (β-TCP) and hydroxyapatite (HA) block impregnated with antibiotics. An 80-year-old male was admitted to our hospital due to cervical spine injury. He had a fistula with pus discharge for 40 years without treatment. His clinical findings were only slight discharge on the left lower leg. Laboratory findings indicated chronic infection. After admission, he had high fever and left shin pain. We curetted and inserted β-TCP block impregnated with imipenem (IPM/CS) and HA block including gentamicin (GM). There were no symptoms or side effects during the nine-month follow-up after operation.