Neurosarcoidosis Without Systemic Sarcoidosis —Case Report—

Masafumi UCHINO; Takeki NAGAO; Naoyuki HARADA; Iekado SHIBATA; Shigeharu HAMATANI; Hiroshi MUTOU

doi:10.2176/nmc.41.48

Case Reports

Neurosarcoidosis Without Systemic Sarcoidosis

—Case Report—

Masafumi UCHINO, Takeki NAGAO, Naoyuki HARADA, Iekado SHIBATA, Shigeharu HAMATANI, Hiroshi MUTOU

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Keywords: sarcoidosis, magnetic resonance imaging, stereotactic biopsy, steroid therapy, neurosarcoidosis

JOURNAL OPEN ACCESS

2001 Volume 41 Issue 1 Pages 48-51

DOI https://doi.org/10.2176/nmc.41.48

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Abstract

A 20-year-old male presented with symptoms of isolated neurosarcoidosis including epilepsy. Magnetic resonance imaging disclosed multiple enhanced right temporal and frontal lesions. Cerebrospinal fluid examination identified mild lymphocytic pleocytosis, and histological examination of a stereotactic brain biopsy specimen demonstrated noncaseating granulomas, so fungal or other inflammatory or granulomatous diseases were excluded. The diagnosis was cerebral sarcoidosis, despite the absence of systemic manifestations. Corticosteroid therapy improved his neurological state and radiological findings. Neurosarcoidosis is a well-recognized occurrence in systemic sarcoidosis, but diagnosis may be difficult in the absence of extracerebral manifestations.

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