Neurocysticercosis as Solitary Parenchymal Lesion Confirmed by Mitochondrial Deoxyribonucleic Acid Sequence Analysis —Case Report—

Eiichi ISHIKAWA; Yoji KOMATSU; Kazunori KIKUCHI; Hiroshi YAMASAKI; Hiroshi KIMURA; Satoru OSUKA; Takao TSURUBUCHI; Akira ITO; Akira MATSUMURA

doi:10.2176/nmc.47.40

Case Reports

Neurocysticercosis as Solitary Parenchymal Lesion Confirmed by Mitochondrial Deoxyribonucleic Acid Sequence Analysis

—Case Report—

Eiichi ISHIKAWA, Yoji KOMATSU, Kazunori KIKUCHI, Hiroshi YAMASAKI, Hiroshi KIMURA, Satoru OSUKA, Takao TSURUBUCHI, Akira ITO, Akira MATSUMURA

Author information

Eiichi ISHIKAWA
Department of Neurosurgery, Ibaraki Prefectural Central Hospital
Department of Neurosurgery, Tsukuba Medical Center Hospital
Yoji KOMATSU
Department of Neurosurgery, Tsukuba Medical Center Hospital
Kazunori KIKUCHI
Department of Pathology, Tsukuba Medical Center Hospital
Hiroshi YAMASAKI
Department of Parasitology, Asahikawa Medical College
Hiroshi KIMURA
Department of Neurosurgery, Tsukuba Medical Center Hospital
Satoru OSUKA
Department of Neurosurgery, Tsukuba Medical Center Hospital
Takao TSURUBUCHI
Department of Neurosurgery, Tsukuba Medical Center Hospital
Akira ITO
Department of Parasitology, Asahikawa Medical College
Akira MATSUMURA
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba

Keywords: intracranial granuloma, neurocysticercosis, magnetic resonance spectroscopy, mitochondrial deoxyribonucleic acid sequence, parenchymal solitary lesion

JOURNAL OPEN ACCESS

2007 Volume 47 Issue 1 Pages 40-44

DOI https://doi.org/10.2176/nmc.47.40

Details

Abstract

A 38-year-old Japanese woman presented with neurocysticercosis manifesting as mild hemiparesis. Magnetic resonance (MR) imaging with gadolinium showed a solitary parenchymal lesion. MR spectroscopy of the mass showed a relatively low N-acetylaspartate peak. Enzyme-linked immunosorbent assay of the patient’s cerebrospinal fluid using antibodies against several parasite antigens was negative. Surgical resection of the lesion was performed. The histological findings showed the possibility of parasitic infection such as neurocysticercosis, although the definitive type of parasite was not confirmed. Sequencing of cytochrome c oxidase subunit 1 gene of mitochondrial deoxyribonucleic acid indicated the Asian genotype of Taenia solium. We propose that these new diagnostic techniques should be used more widely, especially for solitary lesions of neurocysticercosis.

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