No Association between Coding Polymorphism within Exon 4 of the Human Surfactant Protein B Gene and Pulmonary Function in Healthy Men

Stuart M. Raleigh; Benjamin M. Davies; David Cleal; William J. Ribbans

doi:10.2170/physiolsci.SC002607

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No Association between Coding Polymorphism within Exon 4 of the Human Surfactant Protein B Gene and Pulmonary Function in Healthy Men

Stuart M. Raleigh, Benjamin M. Davies, David Cleal, William J. Ribbans

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Keywords: pulmonary function, genotype

JOURNAL FREE ACCESS

2007 Volume 57 Issue 3 Pages 199-202

DOI https://doi.org/10.2170/physiolsci.SC002607

View "Advance Publication" version (June 2, 2007).

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Abstract

The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.

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