Antinociceptive and Anti-inflammatory Activities of Dicranopteris linearis Leaves Chloroform Extract in Experimental Animals

Zainul Amiruddin ZAKARIA; Zuleen Delina Fasya ABDUL GHANI; Raden Nur Suraya RADEN MOHD. NOR; Hanan Kumar GOPALAN; Mohd. Roslan SULAIMAN; Fatimah Corazon ABDULLAH

doi:10.1248/yakushi.126.1197

Article

Antinociceptive and Anti-inflammatory Activities of Dicranopteris linearis Leaves Chloroform Extract in Experimental Animals

Zainul Amiruddin ZAKARIA, Zuleen Delina Fasya ABDUL GHANI, Raden Nur Suraya RADEN MOHD. NOR, Hanan Kumar GOPALAN, Mohd. Roslan SULAIMAN, Fatimah Corazon ABDULLAH

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Keywords: Dicranopteris linearis, chloroform extract, antinociceptive activity, anti-inflammatory activity

JOURNAL FREE ACCESS

2006 Volume 126 Issue 11 Pages 1197-1203

DOI https://doi.org/10.1248/yakushi.126.1197

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Abstract

The present study was carried out to establish the antinociceptive and anti-inflammatory properties of Dicranopteris linearis leaves chloroform extract in experimental animals. The antinociceptive activity was measured using the abdominal constriction, formalin and hot plate tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by evaporation under vacuo (40°C) to dryness, was dissolved in dimethyl sulfoxide to the doses of 20, 100 and 200 mg/kg and administered subcutaneously 30 min prior to subjection to the above mentioned assays. The extract, at all doses used, was found to exhibit significant (p<0.05) antinociceptive activity in a dose-dependent manner. However, the significant (p<0.05) anti-inflammatory activity observed occur in a dose-independent manner. As a conclusion, the chloroform extract of D. linearis possesses antinociceptive and anti-inflammatory activity and thus justify its traditional uses by the Malays to treat various ailments.

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