YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
誌上シンポジウム
グルタミン酸による消化管粘膜保護作用
天ヶ瀬 紀久子中村 英志加藤 伸一竹内 孝治
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2011 年 131 巻 12 号 p. 1711-1719

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  Glutamate is known as the umami substance in the diet and umami taste has been traditionally preferred in East Asian countries. Recent our and others' studies showed that glutamate has potential to protect the gastrointestinal mucosa against noxious agents. In contrast, Helicobacter pylori infection and non-steroidal anti-inflammatory drugs (NSAIDs) are recognized as the two major causes of gastrointestinal diseases characterized by gastritis or gastrointestinal ulcers. We examined whether dietary supplementation of glutamate prevents the Helicobacter pylori infection- and NSAIDs-induced gastrointestinal damages in animal models. In this paper, we first review how these noxious agents develop gastrointestinal damages, and secondly discuss the possible candidates of protective factors as well as the mechanisms how glutamate prevents these gastrointestinal damages. We propose that our daily intake of glutamate has important roles in protecting the gastrointestinal mucosa against Helicobacter pylori and NSAIDs and possibly contributes to the maintenance of our healthy lives.

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© 2011 by the PHARMACEUTICAL SOCIETY OF JAPAN
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