TUNICAMYCIN, A NEW ANTIBIOTIC. I ISOLATION AND CHARACTERIZATION OF TUNICAMYCIN

AKIRA TAKATSUKI; KEI ARIMA; GAKUZO TAMURA

doi:10.7164/antibiotics.24.215

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

TUNICAMYCIN, A NEW ANTIBIOTIC. I

ISOLATION AND CHARACTERIZATION OF TUNICAMYCIN

AKIRA TAKATSUKI, KEI ARIMA, GAKUZO TAMURA

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JOURNAL FREE ACCESS

1971 Volume 24 Issue 4 Pages 215-223

DOI https://doi.org/10.7164/antibiotics.24.215

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Abstract

Tunicamycin is a new antiviral antibiotic produced by Streptomyces lysosuperificus, nov. sp. The active substance in culture broth is purified by solvent extraction followed by chromatography on silicic acid. It has a mole- cular weight of about 870. The antibiotic is active against animal and plant viruses, Gram-positive bacteria, yeast and fungi. Tunicamycin is similar in some properties to a few known antibiotics but differs from them in certain special characteristics.

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