The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
NEW RIFAMYCINS MODIFIED AT POSITIONS 3 AND 4 SYNTHESIS, STRUCTURE AND BIOLOGICAL EVALUATION
L. MARSILI, C. R. PASQUALUCCI, A. VIGEVANI, B. GIOIA, G. SCHIOPPACASSI, G. ORONZO
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1981 Volume 34 Issue 8 Pages 1033-1038

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Abstract

A number of semisynthetic rifamycin derivatives modified at positions 3 and/or 4, belonging to general structures 3, 5, and 6 (see Scheme 1), have been prepared. The synthesis, structure and antimicrobial evaluation of the new compounds are described. All the derivatives have "in vitro" antibacterial activities well comparable with that of rifampicin.

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The Journal of Antibiotics, Series A

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