The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
XANTHOCILLIN X MONOMETHYL ETHER, A POTENT INHIBITOR OF PROSTAGLANDIN BIOSYNTHESIS
NOBUAKI KITAHARAAKIRA ENDO
Author information
JOURNAL FREE ACCESS

1981 Volume 34 Issue 12 Pages 1556-1561

Details
Abstract

Xanthocillin X monomethyl ether, known as an antiviral antibiotic, was isolated as a potent inhibitor of ichotomomyces cejpii. The compound inhibited prostaglandin synthesis from 14C-arachidonic acid in rabbit kidney microsomes by 50% at a concentration of 0.2 μM, while prostaglandin synthesis by microsomes of ram seminal vesicle was inhibited by 50% at 20 μM. The inhibition by xanthocillin X monomethyl ether was reversible. Of the enzymatic steps involved in the synthesis of prostaglandins and thromboxanes tested, conversion of arachidonic acid into prostaglandin H2 was specifically inhibited by xanthocillin X monomethyl ether. Anti-inflammatory activity of this antibiotic on carrageenan-induced oedema in the rat foot was, however, not detectable.

Content from these authors
© Japan Antibiotics Research Association
Previous article Next article
feedback
Top