The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
A GENETIC APPROACH TO THE BIOSYNTHESIS OF THE RIFAMYCINCHROMOPHORE IN NOCARDIA MEDITERRANEI
III. ISOLATION AND IDENTIFICATION OF AN EARLY AROMATIC ANSAMYCINPRECURSOR CONTAINING THE SEVEN-CARBON AMINO STARTER-UNIT AND THREE INITIAL ACETATE/PROPIONATE-UNITS OF THE ANSA CHAIN
ORESTE GHISALBAHERMANN FUHRERWILHELM J. RICHTERSERGE MOSS
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1981 Volume 34 Issue 1 Pages 58-63

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Abstract

A number of rifamycin non-producing UV-mutants derived from Nocardia mediterranei strains N813 (rifamycin B producer) and A101) (aro-mutant excreting shikimate derived from strain N813) were found to accumulate an identical complex of aromatic components instead of rifamycin B. The main component of this aromatic complex, product P8/1-OG, was isolated from six of these P--mutant strains and identified spectroscopically as a very early precursor in the biosynthesis of rifamycins.

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© Japan Antibiotics Research Association
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