16, 17-DIHYDRORIFAMYCIN S AND 16, 17-DIHYDRO-17- HYDROXYRIFAMYCIN S, TWO NOVEL RIFAMYCINS FROM A RECOMBINANT STRAIN C 5/42 OF NOCARDIA MEDITERRANEI

P. TRAXLER; TH. SCHUP; W. WEHRLI

doi:10.7164/antibiotics.35.594

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

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Volume 35 (1982) Issue 5
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16, 17-DIHYDRORIFAMYCIN S AND 16, 17-DIHYDRO-17- HYDROXYRIFAMYCIN S, TWO NOVEL RIFAMYCINS FROM A RECOMBINANT STRAIN C 5/42 OF NOCARDIA MEDITERRANEI

P. TRAXLER, TH. SCHUP, W. WEHRLI

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JOURNAL FREE ACCESS

1982 Volume 35 Issue 5 Pages 594-601

DOI https://doi.org/10.7164/antibiotics.35.594

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Abstract

The structures of 16, 17-dihydrorifamycin S and 16, 17-dihydro-17-hydroxyrifamycin S, two novel ansamycins from the recombinant strain C 5/42 of Nocardia mediterranei, were elucidated by physico-chemical methods. In addition structure-activity relationships among 16, 17-hydrogenated rifamycins are discussed.

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