The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
THE MYXOPYRONINS, NEW INHIBITORS OF BACTERIAL RNA SYNTHESIS FROM MYXOCOCCUS FULVUS (MYXOBACTERALES)
H. IRSCHIKK. GERTHG. HÖFLEW. KOHLH. REICHENBACH
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JOURNAL FREE ACCESS

1983 Volume 36 Issue 12 Pages 1651-1658

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Abstract

From the culture supernatant of the myxobacterium, Myxococcus fulvus strain Mx f50, an antibiotic activity was isolated which blocked growth of many Gram-positive and several Gram-negative bacteria, but not of yeasts and fungi. The activity consisted of two closely related compounds, myxopyronins A and B. The myxopyronins appear to be new antibiotics, and seem to specifically inhibit bacterial RNA polymerase.

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© Japan Antibiotics Research Association
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