METABOLIC PRODUCTS OF MICROORGANISMS. 224 BAFILOMYCINS, A NEW GROUP OF MACROLIDE ANTIBIOTICS PRODUCTION, ISOLATION, CHEMICAL STRUCTURE AND BIOLOGICAL ACTIVITY

GERHARD WERNER; HANSPAUL HAGENMAIER; HANNELORE DRAUTZ; ANGELIKA BAUMGARTNER; HANS ZÄHNER

doi:10.7164/antibiotics.37.110

METABOLIC PRODUCTS OF MICROORGANISMS. 224

BAFILOMYCINS, A NEW GROUP OF MACROLIDE ANTIBIOTICS PRODUCTION, ISOLATION, CHEMICAL STRUCTURE AND BIOLOGICAL ACTIVITY

GERHARD WERNER, HANSPAUL HAGENMAIER, HANNELORE DRAUTZ, ANGELIKA BAUMGARTNER, HANS ZÄHNER

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JOURNAL FREE ACCESS

1984 Volume 37 Issue 2 Pages 110-117

DOI https://doi.org/10.7164/antibiotics.37.110

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Abstract

The bafilomycins A₁, A₂, B₁, B₂, C₁ and C₂, a new type of macrolide antibiotics with a 16-membered lactone ring, were isolated from the fermentation broth of three Streptomyces griseus strains (TÜ 1922, TÜ 2437, TÜ 2599) by ethyl acetate extraction and column chromatography on silica gel. The bafilomycins exhibit activity against Gram-positive bacteria and fungi. Physico-chemical data, chemical structures and biological activities are reported.

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