NEW ANTIBIOTICS FROM GENETICALLY ENGINEERED ACTINOMYCETES I. 2-NORERYTHROMYCINS, ISOLATION AND STRUCTURAL DETERMINATIONS

JAMES B. MCALPINE; JAMES S. TUAN; DAVID P. BROWN; KEVIN D. GREENER; DAVID N. WHITTERN; ALEX BUKO; LEONARD KATZ

doi:10.7164/antibiotics.40.1115

NEW ANTIBIOTICS FROM GENETICALLY ENGINEERED ACTINOMYCETES

I. 2-NORERYTHROMYCINS, ISOLATION AND STRUCTURAL DETERMINATIONS

JAMES B. MCALPINE, JAMES S. TUAN, DAVID P. BROWN, KEVIN D. GREENER, DAVID N. WHITTERN, ALEX BUKO, LEONARD KATZ

Author information

JAMES B. MCALPINE
Anti-infective Research, Pharmaceutical Products Division and Corporate Molecular Biology, Abbott Diagnostic Division, Abbott Laboratories
JAMES S. TUAN
Anti-infective Research, Pharmaceutical Products Division and Corporate Molecular Biology, Abbott Diagnostic Division, Abbott Laboratories
DAVID P. BROWN
Anti-infective Research, Pharmaceutical Products Division and Corporate Molecular Biology, Abbott Diagnostic Division, Abbott Laboratories
KEVIN D. GREENER
Anti-infective Research, Pharmaceutical Products Division and Corporate Molecular Biology, Abbott Diagnostic Division, Abbott Laboratories
DAVID N. WHITTERN
Anti-infective Research, Pharmaceutical Products Division and Corporate Molecular Biology, Abbott Diagnostic Division, Abbott Laboratories
ALEX BUKO
Anti-infective Research, Pharmaceutical Products Division and Corporate Molecular Biology, Abbott Diagnostic Division, Abbott Laboratories
LEONARD KATZ
Anti-infective Research, Pharmaceutical Products Division and Corporate Molecular Biology, Abbott Diagnostic Division, Abbott Laboratories

JOURNAL FREE ACCESS

1987 Volume 40 Issue 8 Pages 1115-1122

DOI https://doi.org/10.7164/antibiotics.40.1115

Details

Abstract

Novel macrolide antibiotics have been isolated from a genetically manipulated actinomycete. The major components produced have been isolated and identified as 2-norerythromycins A, B, C and D by mass spectrometry and extensive ID and 2D NMR experiments.

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